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Drug Development and Industrial Pharmacy Volume 25, 1999 - Issue 12
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Research Article

Physicochemical Characterization of YJA20379-8, a New Proton Pump Inhibitor

Jungjoo Kim Department of Formulation, Central Research and Development Laboratory, Yungjin Pharmaceutical Company, Limited, Musong-ri, Ky., 470-5, U.S.A.
,
Chongjeon Park Department of Formulation, Central Research and Development Laboratory, Yungjin Pharmaceutical Company, Limited, Musong-ri, Ky., 470-5, U.S.A.
,
Mansik Chang Department of Formulation, Central Research and Development Laboratory, Yungjin Pharmaceutical Company, Limited, Musong-ri, Ky., 470-5, U.S.A.
,
Jungkwon Cha Department of Formulation, Central Research and Development Laboratory, Yungjin Pharmaceutical Company, Limited, Musong-ri, Ky., 470-5, U.S.A.
,
Jeongmin Lee Department of Formulation, Central Research and Development Laboratory, Yungjin Pharmaceutical Company, Limited, Musong-ri, Ky., 470-5, U.S.A.
&
Youngkuk Chung Department of Formulation, Central Research and Development Laboratory, Yungjin Pharmaceutical Company, Limited, Musong-ri, Ky., 470-5, U.S.A.
Pages 1283-1287 | Published online: 12 Jul 1999
 
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Abstract

The physicochemical properties of the potent reversible proton pump inhibitor YJA20379-8, 3-butyryl-4-[(R)-1-methylbenzylamino]-8-ethoxy-1,7-naphthyridine, were studied. YJA20379-8 is essentially nonhygroscopic pale yellowish crystalline powder. It is practically insoluble in water, and its lipid solubility is high. The pH solubility profile exhibits an L-shaped curve, indicating YJA20379-8 is a basic substance having a soluble ionized form in acidic conditions. This is consistent with the result of an experiment to determine pKa. The solid-state stability study shows that YJA20379-8 is stable at various temperatures and humidities, but is decomposed by light.

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