Nanoparticle Engineering Processes for Enhancing the Dissolution Rates of Poorly Water Soluble Drugs

Abstract

Poor water solubility is an industry wide issue, especially for pharmaceutical scientists in drug discovery and drug development. In recent years, nanoparticle engineering processes have become promising approaches for the enhancement of dissolution rates of poorly water soluble drugs. Nanoparticle engineering enables manufacturing of poorly water soluble drugs into nanoparticles alone, or incorporation with a combination of pharmaceutical excipients. The use of these processes has dramatically improved in vitro dissolution rates and in vivo bioavailabilities of many poorly water soluble drugs. This review highlights several commercially or potentially commercially available nanoparticle engineering processes recently reported in the literature for increasing the dissolution properties of poorly water soluble drugs.

Key Words:

• Nanoparticle engineering process
• Poorly water soluble drug
• Water insoluble drug
• Nanoparticle
• Solubility
• Dissolution
• Bioavailability
• Drug delivery
• Particle engineering
• Wet milling
• High pressure homogenization
• PCA
• SEDS
• SAS
• RESAS
• SFL
• EPAS