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Immunopharmacology and Immunotoxicology Volume 23, 2001 - Issue 3
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Research Article

ANTI-INFLAMMATORY EFFECTS OF THEOPHYLLINE: MODULATION OF IMMUNE FUNCTIONS DURING MURINE LEUKEMIA VIRUS INFECTION

Bailin Liang College of Public Health and School of Medicine, University of Arizona, Tucson, AZ, 85724, U.S.A.
,
Shuguang Jiang College of Public Health and School of Medicine, University of Arizona, Tucson, AZ, 85724, U.S.A.
,
Zhen Zhang College of Public Health and School of Medicine, University of Arizona, Tucson, AZ, 85724, U.S.A.
,
Paula Inserra College of Public Health and School of Medicine, University of Arizona, Tucson, AZ, 85724, U.S.A.
,
Jeongmin Lee College of Public Health and School of Medicine, University of Arizona, Tucson, AZ, 85724, U.S.A.
,
David Solkoff College of Public Health and School of Medicine, University of Arizona, Tucson, AZ, 85724, U.S.A.
&
Ronald R. Watson College of Public Health and School of Medicine, University of Arizona, P.O. Box 245155, 1501 N. Campbell Ave., Tueson, AZ, 85724, U.S.A.; College of Public Health and School of Medicine, University of Arizona, Tucson, AZ, 85724, U.S.A.
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Pages 307-319 | Published online: 31 Jul 2001
 
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Abstract

LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL/6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Th1 cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment.

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