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Immunopharmacology and Immunotoxicology Volume 24, 2002 - Issue 3
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Research Article

INHIBITORY EFFECT OF ARTEMISIA CAPILLARIS ON ETHANOL-INDUCED CYTOKINES (TNF-α, IL-1α) SECRETION IN HEP G2 CELLS

Hyun-Na Koo Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, and KI Co. Ltd., Iksan, Jeonbuk, 570-749, South Korea
,
Seung-Heon Hong Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, and KI Co. Ltd., Iksan, Jeonbuk, 570-749, South Korea
,
Hyun-Ja Jeong Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, and KI Co. Ltd., Iksan, Jeonbuk, 570-749, South Korea
,
Eun-Hee Lee Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, and KI Co. Ltd., Iksan, Jeonbuk, 570-749, South Korea
,
Nam-Guek Kim Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, and KI Co. Ltd., Iksan, Jeonbuk, 570-749, South Korea
,
Su-Deock Choi Department of Internal Medicine, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea
,
Ki-Woong Ra Department of Internal Medicine, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea
,
Kang-San Kim Department of Internal Medicine, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea
,
Byung-Ki Kang Department of Internal Medicine, College of Oriental Medicine, Wonkwang University, Iksan, Jeonbuk, 570-749, South Korea
,
Jeong-Joong Kim Department of Anatomy, Wonkwang University School of Medicine, Iksan, Jeonbuk, 570-749, South Korea
,
Jeong Guk Oh
&
Hyung-Min Kim Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, and KI Co. Ltd., Iksan, Jeonbuk, 570-749, South Korea
 show all
Pages 441-453 | Published online: 09 Sep 2002
 
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ABSTRACT

A human hepatoma cell line, Hep G2 cell, is reliable for the study of alcohol-induced hepatotoxicity. In this study, we investigated the effect of an aqueous extract of Artemisia capillaris THUNB (Compositae) plant (AC) on ethanol (EtOH)-induced cytotoxicity in Hep G2 cells. AC (0.5–5 µg/mL) inhibited the secretion of EtOH-induced interluekin-1α (IL-1α) and tumor necrosis factor-α (TNF-α). AC also inhibited the EtOH-, IL-1α-, and TNF-α-induced cytotoxicity. Furthermore, we found that AC inhibited the EtOH-induced apoptosis of Hep G2 cells. These results suggest that AC may prevent the EtOH-induced cytotoxicity through inhibition of the apoptosis of Hep G2 cells.

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