Abstract
International guidelines recommend prescription of inhaled corticosteroïds to improve asthma control. Chronic secondary adrenal suppression due to inhaled corticosteroids has been described. We report a case of acute adrenal suppression due to drug interaction between Fluticasone and antiretroviral therapy in a HIV patient. Seeing an increased prevalence of hyperresponsiveness among HIV‐infected men, we conclude that coprescription of Fluticasone and highly active antiretroviral therapy must be carefully controlled.