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Abstract
Electroporative drug delivery (electroloading of cells) takes place effectively by inserting electrodes mediating strong electric pulses. Another possibility is the disturbance of lipid bilayer structures by weak pulsating electromagnetically induced currents (PEMIC) produced by Helmholtz coils. In yeast cells (Saccharomyces cerevisiae) the enhancement of drug (sensitizer) transport through cell membranes by PEMIC results in an increased photodynamic cell killing. Depending on the magnetic flux, a window of 25% killing rate, caused by the photodynamic effect, could be observed at approximately 8 mT with a frequency of 50 Hz.