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Journal of Liposome Research Volume 12, 2002 - Issue 1-2
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Research Article

THE NEXT GENERATION OF LIPOSOME DELIVERY SYSTEMS: RECENT EXPERIENCE WITH TUMOR-TARGETED, STERICALLY-STABILIZED IMMUNOLIPOSOMES AND ACTIVE-LOADING GRADIENTS

R. M. Abra ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.
,
R. B. Bankert ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.
,
F. Chen Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, 14263, U.S.A.
,
N. K. Egilmez Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, 14263, U.S.A.
,
K. Huang ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.
,
R. Saville ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.
,
J. L. Slater ALZA Corp., Mountain ViewCalifornia, 94025, U.S.A.
,
M. Sugano Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, 14263, U.S.A.
&
S. J. Yokota Department of Immunology, Roswell Park Cancer Institute, Buffalo, New York, 14263, U.S.A.
 show all
Pages 1-3 | Published online: 15 Jul 2002
 
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ABSTRACT

Three topics are discussed. Enhanced anti-tumor efficacy of targeted doxorubicin-containing sterically-stabilized liposomes using an anti-β1 integrin Fab’ ligand. Use of tumor targeting with an internalizing ligand to improve the efficacy of a non-leaky cisplatin-containing sterically-stabilized liposome formulation. Formulation variables (remote-loading with dextran ammonium sulfate, rigid lipid bilayer) used to optimize in vivo performance of a liposomal camptothecin analog.

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