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Journal of Liposome Research Volume 12, 2002 - Issue 1-2
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Research Article

CLODRONATE LIPOSOMES: PERSPECTIVES IN RESEARCH AND THERAPEUTICS

Nico van Rooijen Department of Molecular Cell Biology, Faculty of Medicine, Research Institute of Immunology & Inflammation, Vrije Universiteit Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands
&
Esther van Kesteren-Hendrikx Department of Molecular Cell Biology, Faculty of Medicine, Research Institute of Immunology & Inflammation, Vrije Universiteit Van der Boechorststraat 7, Amsterdam, 1081 BT, The Netherlands
Pages 81-94 | Published online: 15 Jul 2002
 
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ABSTRACT

Liposomes encapsulating the bisphosphonate clodronate can be used for the transient suppression of macrophage functions. Given the important role of macrophages in various disorders, the application of clodronate liposomes has been studied in several models of rheumatoid arthritis, neurological disorders such as experimental allergic encephalomyelitis and spinal cord injury, autoantibody mediated disorders such as immune thrombocytopenic purpura (ITP) and for the improvement of the efficacy of gene transfer and drug targeting.

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