Advanced search
Publication Cover
Journal of Liposome Research Volume 12, 2002 - Issue 1-2
Submit an article Journal homepage
69
Views
12
CrossRef citations to date
0
Altmetric
Research Article

OPTIMIZATION OF CATIONIC LIPID MEDIATED GENE TRANSFER: STRUCTURE-FUNCTION, PHYSICO-CHEMICAL, AND CELLULAR STUDIES

Marie Carrière Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France
,
Isabelle Tranchant Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France
,
Pierre-Antoine Niore Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France
,
Gerardo Byk Department of Chemistry, Laboratory of Peptidomimetics and Genetic Chemistry, Bar-Ilan University, Ramat Gan, 52900, Israel
,
Nathalie Mignet Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France
,
Virginie Escriou Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France
,
Daniel Scherman Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France
&
Jean Herscovici Laboratoire de Chimie Bioorganique et de Biotechnologie Moléculaire et Cellulaire, UMR 7001 CNRS ENSCP, Aventis ENSCP, 11 rue Pierre et Marie Curie, 75013 Paris and CRVA Aventis Pharma, 13 quai Jules Gesde B.P. 14, 94403Vitry sur Seine, France
 show all
Pages 95-106 | Published online: 15 Jul 2002
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

ABSTRACT

The rationale design aimed at the enhancement of cationic lipid mediated gene transfer is discussed. These improvements are based on the straight evaluation of the structure-activity relationship and on the introduction of new structures. Much attention have been given to the supramolecular structures of the lipid/DNA complexes, to the effect of serum on gene transfer and to the intracellular trafficking of the lipoplexes. Finally new avenue using reducible cationic lipids has been discussed.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,410.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.