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Journal of Liposome Research Volume 12, 2002 - Issue 1-2
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Research Article

LIPOSOME-ENABLED SYNERGISTIC INTERACTION OF ANTIMICROBIAL AGENTS

Raymond M. Schiffelers Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, The Netherlands
,
Gert Storm Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht, The Netherlands
,
Marian T. ten Kate Dept of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam (EMCR), Rotterdam, The Netherlands
,
Lorna E. T. Stearne-Cullen Dept of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam (EMCR), Rotterdam, The Netherlands
,
Jan G. den Hollander Dept of Internal Medicine, Zuiderziekenhuis, Rotterdam, The Netherlands
,
Henri A. Verbrugh Dept of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam (EMCR), Rotterdam, The Netherlands
&
Irma A. J. M. Bakker-Woudenberg Dept of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam (EMCR), Rotterdam, The Netherlands
 show all
Pages 121-127 | Published online: 15 Jul 2002
 
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ABSTRACT

Antimicrobial agents may interact synergistically when both drugs are present at the infected site for an adequate period of time at sufficient concentrations. Generally speaking, the agents in the combination show different tissue distributions and pharmacokinetics. By co-encapsulation of the drugs in a drug carrier, like liposomes, parallel tissue distributions of both drugs may be ensured and drug concentrations at the site of infection may be increased. In this presentation therapeutic efficacy of liposome-co-encapsulated gentamicin (GN) and ceftazidime (CZ) will be shown in a GN-CZ-susceptible and GN-CZ-resistant Klebsiella pneumoniae-pneumonia in rats.

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