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Journal of Liposome Research Volume 12, 2002 - Issue 1-2
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Research Article

LIGAND-TARGETED LIPOSOMES DIRECTED AGAINST PATHOLOGICAL VASCULATURE

Raymond M. Schiffelers Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), P.O. Box 80082, TB Utrecht, 3508, The Netherlands
,
Grietje Molema Dept. Pathology and Laboratory Medicine, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands
,
Timo L. M. ten Hagen Dept. of Surgical Oncology, Academic Hospital Rotterdam - Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
,
Adriënne P. C. A. Janssen Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), P.O. Box 80082, TB Utrecht, 3508, The Netherlands
,
Astrid J. Schraa Dept. Pathology and Laboratory Medicine, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands
,
Robbert J. Kok Dept. of Pharmacokinetics and Drug Delivery, GUIDE, Groningen, The Netherlands
,
Gerben A. Koning Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), P.O. Box 80082, TB Utrecht, 3508, The Netherlands
&
Gert Storm Dept. of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), P.O. Box 80082, TB Utrecht, 3508, The Netherlands
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Pages 129-135 | Published online: 15 Jul 2002
 
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ABSTRACT

The development of liposomes targeted to angiogenic endothelial cells offers exciting prospects for intervention in cancer and inflammation. Several proteins are (strongly) over-expressed on angiogenic endothelial cells as compared to the quiescent endothelium, and could potentially serve as targets for site-specific drug delivery. In this contribution particular attention is given to the design of targeted long-circulating liposomes directed against the alpha v beta 3-integrin protein.

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