Abstract
Piperdardine, (E,E)-1-[7-(1,3-benzodioxol-5-yl)-1-oxo-2,4-heptadienyl]-piperidine, isolated from the stem of Piper tuberculatum, was synthesized in 21% overall yield by an efficient pathway, in which safrole, an abundant Brazilian essential oil from Ocotea pretiosa, was used as starting material.
ACKNOWLEDGMENTS
The authors are grateful to CNPq (# 52.0033/96-5), CAPES, FUJB, and PRONEX-0888 (Brazil) for financial assistance and fellowships. We are also thankful to NPPN Analytical Center and IQ-UFRJ (Brazil) for spectroscopic analysis, as well as to Prof. Claudio L. Donnici (DQ-ICEx-UFMG).
Notes
†This paper represents the contribution # 45 from LASSBio.