SYNTHESIS OF 2-ALKYL AND 2-ARYL PYRIMIDINES FROM β-CHLOROVINYL KETONES OF CYCLOPENTANONE TYPE

Abstract

Amidines react in the presence of NaHCO₃ with β-chlorovinyl ketones, prepared regioselectively by the reaction of 2-acetylcyclo- pentanone-type diketones with PPh₃-CCl₄ in 73–78% yield, to afford 2-alkyl (aryl)-pyrimidines annelated with cyclopentane derivatives in 79–87% yields.

ACKNOWLEDGMENTS

The authors thank the Russian Foundation for Basic Research (grant no. 98-03-32910 a) and INTAS (grant # 97-0217) for the financial support of this work.