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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 31, 2001 - Issue 18
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Original Articles

SYNTHESIS OF IDEBENONE; A SYNTHETIC ANALOG OF COENZYME Q

Young-Sik Jung Bioorganic Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yusong, Taejon, 305 606, Korea
,
Bo-Young Joe Bioorganic Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yusong, Taejon, 305 606, Korea
,
Churl-Min Seong Bioorganic Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yusong, Taejon, 305 606, Korea
&
No-Sang Park Bioorganic Division, Korea Research Institute of Chemical Technology, P.O. Box 107, Yusong, Taejon, 305 606, Korea
Pages 2735-2741 | Received 31 Jul 2000, Published online: 15 Aug 2006
 
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Abstract

Idebenone, a synthetic analog of coenzyme Q, was prepared from the tetramethoxytoluene 2. Two main transformations in this procedure are Friedel-Crafts acylation of 2 to 4 and CAN assisted oxidation of 7 to the quinone 8.

ACKNOWLEDGMENTS

Financial support of this work by the Ministry of Science and Technology in Korea is gratefully acknowledged.

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