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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 7
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Original Articles

A Facile Synthesis of 3‐Substituted Phthalides

Guo Li Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100050, P.R. China
,
Dali Yin Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100050, P.R. ChinaCorrespondence[email protected]
&
Xiao‐Tian Liang Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100050, P.R. China
Pages 1183-1189 | Received 08 May 2003, Published online: 21 Aug 2006
 
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Abstract

1(3H)‐Isobenzofuranone (phthalides) and its derivatives possess a wide range of biological activities. A new method was found for the synthesis of 3‐substituted phthalides featured with the convenient condensation reaction of 3‐ethoxyphthalide with carbanions in high yields.

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