An Efficient Synthesis of α‐(2,4‐Dichloro‐phenoxyacetoxy)aryl Methyl Phosphonate Monosodium Salts

Abstract

A series of α‐(2,4‐dichlorophenoxyacetoxy)aryl methyl phosphonate monosodium salts 6 were synthesized by the reaction of the intermediate 5 with sodium iodide under moderate condition. This method was applied to the synthesis of novel phosphonate derivatives containing sensitive groups such as carboxylic ester to acid, base, or water.

Keywords:

• Phosphonate monosodium salt
• Synthesis
• Pyruvate dehydrogenase
• Carboxylic ester

Acknowledgments

We gratefully acknowledge financial support of this work by National Natural Science Foundation of China (Project No: 29572045, 20072008, 20372023).