Synthesis of (−)‐Mintlactone via Intramolecular Wittig–Horner Reaction

Abstract

An efficient synthesis of (−)‐mintlactone has been described starting from (+)‐pulegone and employing the intramolecular Wittig–Horner reaction as the key step.

Keywords:

• Mintlactone
• Intramolecular Wittig–Horner reaction
• Phosphonate
• Stereoselectivity

Acknowledgments

RKP thanks CSIR, New Delhi for award of senior research fellowship. We are grateful to Dr. M. K. Gurjar, Head, Organic Chemistry: Technology Division for his constant encouragement and support. This is NCL communication No. 6657.

Notes

^aThe enantiomeric excess was determined by HPLC. HPLC model: Merck‐Hitachi Lachrom PDA system D‐7000 series; Column: Lichrospher RP‐18 (4 mm ID × 125 mm); Mobile phase: methanol: water: (90:10); Flow: 1 mL/min.