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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 34, 2004 - Issue 13
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Original Articles

Efficient Synthesis of Polyethylene Glycol Mono‐Carboxylate via Michael Conjugate Addition

Qingqi Chen Biomarin Pharmaceutical Inc., 46 Galli Drive, Novato, California, 94949, USACorrespondence[email protected]
&
Reinhard Gabathuler Biomarin Pharmaceutical Inc., 46 Galli Drive, Novato, California, 94949, USA
Pages 2425-2432 | Received 03 Mar 2004, Published online: 10 Jan 2011
 
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Abstract

Poly(ethylene glycol) (PEG) with one carboxylate group, the very useful precursors for the synthesis of the PEG derived heterobifunctional linkers, are synthesized in high yield in one‐pot via Michael conjugate addition of acrylate esters with PEG and catalyst amount of sodium in THF.

Notes

aA number of companies are providing heterobifunctional linkers: such as Pierce Inc. Sigma–Aldrich, Solulink Inc.

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