Abstract
A series of acyclic chiral nitroxides bearing a hydrogen atom on the carbon adjacent to the nitroxide nitrogen was investigated for stereoselectivity in a coupling reaction with the prochiral radical 1‐phenethyl. In one case, an x‐ray structure of the major diastereomer was obtained, which corroborates a model for predicting the stereoselectivity.
Acknowledgments
Financial support from the National Science Foundation (CHE 9527647 and CHE 0078852) is gratefully acknowledged.
Notes
aThe crystallographic data for 6a has been deposited with the Cambridge Crystallographic Data Center as supplementary publication no. CCDC 205620. These data can be obtained free of charge via www.ccdc.cam.ac.uk/conts/retrieving.html (or from the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033; e‐mail: [email protected]).