Microwave‐Assisted One‐Step Synthesis of Substituted 2‐Chloromethyl‐1,3,4‐oxadiazoles

Abstract

We have developed a simple one‐step synthesis of 2‐chloromethyl‐1,3,4‐oxadiazoles from commercially available acylhydrazides using 1‐chloro‐2,2,2‐trimethoxyethane as a solvent under microwave irradiation.

Acknowledgments

We would like to thank Dr. David Lustig and Mr. Irving Fong for their help with liquid chromatography and mass‐spectrometry, and Dr. Brent Blackburn for helpful discussions.

Notes

^aSmith Process Vial and Emrys Optimizer are registered trademarks of Personal Chemistry, Inc., Uppsala.