Abstract
α‐Cyano‐β‐enaminones, obtained by regioselective acylation of β‐enaminonitriles, were smoothly converted to thiones which on oxidative cyclization afforded 3,5‐disubstituted‐4‐isothiazolecarbonitriles in good to excellent yields.
Acknowledgments
We are thankful to Dr. W. Froestl, Novartis Pharma AG, Basel, Switzerland; Dr. V. A. Snieckus, Queens University, Ontario, Canada; Dr. R. Mukherjee, IICB, Kolkata, India for recording spectral data of some of our compounds; Dr. S. Chakraborty, University of Michigan, USA for recording mass spectroscopy of some compounds; and Dr. R. G. Bhattacharya, J. U. for running GC of liquid samples. M. M. thanks Jadavpur University for awarding the State Fellowship.