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Transparency
Declaration of funding
This article was based on a meeting held in Rome, Italy, on June 20th and 21st, 2010, which was supported by Grünenthal GmbH, Aachen, Germany.
Declaration of financial/other interest
A.D. has disclosed that he received an honorarium from Grünenthal GmbH to attend the meeting in Rome.
CMRO peer reviewers may have received honoraria for their review work. The peer reviewers on this manuscript have disclosed that they have no relevant financial relationships.
Acknowledgement
The authors thank Derrick Garwood Ltd, Cambridge, UK, for editorial support, which was sponsored by Grünenthal GmbH, Aachen, Germany.