Statin therapy correlated CYP2D6 gene polymorphism and hyperlipidemia

Abstract

Purpose:

To investigate the distribution of statin therapy correlated gene polymorphism allele CYP2D6*10 (C188T) in Ningxia Hui nationality and to discuss the relationship between the gene polymorphism allele CYP2D6*10 (C188T) and the lipid-lowering efficacy of simvastatin and hyperlipidemia.

Materials and methods:

One hundred and fifty healthy people (80 males and 70 females) and 200 hyperlipidemia patients (105 males and 95 females) were recruited at Ningxia People’s Hospital. Genotypes were determined by using allele-specific amplification (ASA-PCR) in 150 healthy controls and 200 patients with hyperlipidemia. Relationships between genotypes and lipid levels and the lipid-lowering efficacy of simvastatin were analyzed.

Results:

The distribution frequency of the CYP2D6*10 allele was 47.6% in the Ningxia Hui nationality. There was no significant correlation between the CYP2D6*10 allele and hyperlipidemia. At 8 weeks after treatment with simvastatin, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were more obviously decreased with the CC genotype than the CT and TT genotypes, with significant differences.

Conclusion:

Distribution of the gene polymorphism of CYP2D6*10 is ethnically and geographical different. The allele T of CYP2D6*10 is not related to hyperlipidemia. CC expression seemed to increase the lipid-lowering effects of simvastatin. The hyperlipidemia patients with CC genotype should take lower doses of simvastatin than those with CT/TT genotype in the Ningxia Hui population.

Keywords::

• CYP2D6
• Hyperlipidemia
• Individualized therapy
• Polymorphism
• Statins

Transparency

Declaration of funding

This research was supported by the Natural Science Foundation of Ningxia (No. NZ07109); Health Department of key research projects in Ningxia (No. W200707).

J.L. and J.W. conceived the study. J.L., X.W. and Y.C. prepared and analyzed the data. J.Z., X.W. and Z.Z. interpreted the results and finalized the manuscript. J.L. and J.W. were responsible for the conception, overall scientific management, interpretation of results, and critically reviewing of the report. All authors read and approved the final manuscript. The principal investigators (PIs) of this study were J.L. and X.W. Both PIs contributed equally to this article.

Juyi Li

Xiufang Wang

Zhaoqing Zhang

Jili Zou

Yonggang Chen

Xiong Wang

Jinhu Wu

Declaration of financial/other relationships

J.L., X.W., Z.Z., J.Z., Y.C., X.W., and J.W. have disclosed that they have no significant relationships with or financial interests in any commercial companies related to this study or article.

CMRO peer reviewers may have received honoraria for their review work. The peer reviewers on this manuscript have disclosed that they have no relevant financial relationships.

Acknowledgments

The authors thank all the volunteers that participated in this study. We also thank the correspondence authors, J.W. and Z.Z.