Bi-Phasic Effect of Equol on Adipocyte Differentiation of MC3T3-L1 Cells

Yoriko NISHIDEDepartment of Food Function and Labeling, National Institute of Health and Nutrition;Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology

Yuko TOUSENDepartment of Food Function and Labeling, National Institute of Health and Nutrition

Masaki INADACooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology

Chisato MIYAURACooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology

Yoshiko ISHIMIDepartment of Food Function and Labeling, National Institute of Health and Nutrition

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We investigated the effects of equol on adipogenesis by measuring lipid accumulation and analyzing the change in adipocyte-related gene expression in MC3T3-L1 cells. Treatment with 10 µM equol tended to increase adipocyte-related gene expression, whereas 100 µM equol reduced lipid accumulation and suppressed the expression of these genes and proteins. Our results suggest that equol regulated adipogenesis in a bi-phasic fashion.

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Bi-Phasic Effect of Equol on Adipocyte Differentiation of MC3T3-L1 Cells

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