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Expert Opinion on Therapeutic Patents Volume 16, 2006 - Issue 12
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Review

Anticancer activity of artemisinin-derived trioxanes

Gary H Posner Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA; Malaria Research Institute, John Hopkins University, Baltimore, MD 21205, USA
,
John D’Angelo Department of Chemistry, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA; Malaria Research Institute, John Hopkins University, Baltimore, MD 21205, USA
,
Paul M O’Neill Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, UK; Department of Pharmacology and Therapeutics, Sherrington Buildings, University of Liverpool, Liverpool L69 3GE, UK
&
Amy Mercer Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, UK; Department of Pharmacology and Therapeutics, Sherrington Buildings, University of Liverpool, Liverpool L69 3GE, UK
Pages 1665-1672 | Published online: 22 Nov 2006
 
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Abstract

The recent scientific and patent literature on therapeutically promising anticancer trioxanes derived from the antimalarial artemisinin are reviewed through mid-2006. Several of these new chemical entities, especially some trioxane dimers, have selective and very potent anticancer activity even at low nanomolar concentrations. A major opportunity exists for the development of these and related trioxanes into anticancer drug candidates.

Acknowledgment

The NIH (AI-34885) is thanked for financial support of the peroxide chemotherapy research programme at John Hopkins University.

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