Abstract
Importance of the field: New antibiotics are needed to overcome microbial resistance and to improve on the therapeutic index and clinical effectiveness of existing agents.
Area covered in this review: This review covers the journal and patent literature published from about the mid-2000s to 2010 to provide an overview of the large diversity of new chemical entities in the macrolide, lincosaminide and streptogramin B (MLSB) class.
What the reader will gain: The review identifies areas of the greatest effort and recent results in pursuing structure–activity relationships among MLSB antibiotics and highlights preclinical and clinical candidates that have arisen from these diverse discovery programs.
Take home message: Research on the MLSB class appears promising for the eventual registration and commercialization of several new antibiotics that improve the clinical effectiveness of existing agents and combat antibiotic-resistant pathogens.
Notes
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