Correction to: New therapeutic options for onychomycosis
Gupta AK, Simpson FC. Expert Opin Pharmacother 2012;13(8):1131-42.
Following publication of this article, some errors has been identified in the text.
In section 2.1, terbinafine nail solution (TNS) was incorrectly attributed as terbinafine nail lacquer (TNL). All subsequent mentions of TNL throughout the article should read terbinafine nail solution or TNS as appropriate.
A corrected version of section 2.3 (including an additional reference) is as follows:
2.3 NB-002 and NB-00X
NB-002 is a topical antifungal nanoemulsion. NB-002 has been assayed in vitro in comparison with ciclopirox, terbinafine, itraconazole, amphotericin B, tolnaftate, naftifine and griseofulvin. The MIC values for NB-002 were lower than those for all other active comparators Citation[23]. It is fungicidal against T. rubrum, T. mentagrophytes, Microsporum spp, E. floccosum, T. tonsurans, T. soudanense and T. verrucosum. NB-002 has completed Phase II clinical trials (NCT00453271) Citation[24], but the data remain unpublished. NB-002 can also be formulated with 1% terbinafine hydrochloride as NB-00X to improve terbinafine's lateral diffusion in the nail plate Citation[100].
Also, the reference to NB-002 in paragraph 7 of the Expert Opinion section should be amended to NB-00X. The sentence should read:
Iontophoresis uses electric current to increase terbinafine uptake in the nail plate. Terbinafine is the most effective systemic antifungal, but TDT-067, NB-00X and TNS have not been able to replicate these results as topical formulations.
References
- Pannu J, McCarthy A, Martin A, NB-002, a novel nanoemulsion with broad antifungal activity against dermatophytes, other filamentous fungi, and Candida albicans. Antimicrob Agents Chemother 2009;53(8):3273-9
- ClinicalTrials.gov. Treatment of mild to moderate distal subungual onychomycosis of the toenail. Available from: http://clinicaltrials.gov/ct2/show/NCT00453271 [Cited 21 December 2011]
- Ciotti S, Eisma R, Ma L, Lateral diffusion of terbinafine hydrocholride in a novel nanoemulsion. 2009. Available from: http://www.nanobio.com/Dermatology/documents/148098_465_11x17.pdf [Cited 7 November 2012]