Efficacy and safety of fluoxetine monotherapy in bipolar depression: a systematic review

Abstract

Introduction: The treatment of depressive episodes in bipolar disorder (BD) remains a challenge for clinicians and is a hot topic in current psychiatric practice. In the present review, we focused on efficacy and safety of fluoxetine monotherapy in order to identify published randomized double-blind trials and open-label trials, written in English, reporting the outcome of fluoxetine treatment in depressed bipolar patients.

Areas covered: We searched Pubmed to identify published randomized double-blind trials and open-label trials, written in English, reporting the results of fluoxetine treatment in depressed bipolar patients. The following key words were used: fluoxetine AND bipolar AND depression AND treatment. A total number of seven prospective studies (four randomized clinical trials and three open-label trials) and one two-phase retrospective study were reviewed.

Expert opinion: Fluoxetine showed to be efficacious in bipolar depression, confirming its well-known activity in major depressive episodes, with a low percentage of mood switch, despite the general view that antidepressants may increase the rate of manic/hypomanic episodes in BDs. More studies with larger sample sizes, comparing fluoxetine with other antidepressants, mood stabilizers and antipsychotics are needed.

Keywords::

• bipolar depression
• bipolar disorder
• fluoxetine
• mood switch

Declaration of interest

The authors state no conflict of interest and have received no payment in preparation of this manuscript. The paper was funded by the Department of Neuroscience and Imaging, University “G d'Annunzio”, Chieti-Pescara