Is methylphenidate a safe and effective treatment for ADHD-like symptoms in children with pervasive developmental disorders?

Abstract

Children with autistic disorder and related pervasive developmental disorders (PDDs) frequently have symptoms of hyperactivity and impulsivity similar to the symptoms of attention-deficit/hyperactivity disorder (ADHD). Clinicians often treat these symptoms with methylphenidate (MPH), but historically there are little available data about the use of MPH in children with PDD. The Research Units on Pediatric Psychopharmacology (RUPP) group set out to determine whether MPH is a safe and effective treatment for the ADHD-like symptoms associated with PDD. MPH was found to be superior to placebo in reducing hyperactivity scores on the Aberrant Behavior Checklist. However, there was a lower magnitude of response and a higher incidence of medication discontinuation than previously reported in typically developing children with ADHD. Although MPH seems to be a reasonable choice for the treatment of ADHD-like symptoms in children with PDD, clinicians should consider the findings from the RUPP MPH study before prescribing MPH to children with PDD.

Keywords::

• ADHD
• Asperger’s disorder
• attention-deficit/hyperactivity disorder
• autism
• autistic disorder
• methylphenidate
• pervasive developmental disorder

Disclosure

Dr N L Miller has no financial, commercial or other relationships of a declarable nature. Dr R L Findling receives or has received research support, acted as a consultant and/or served on a speaker’s bureau for Abbott, AstraZeneca, Bristol-Myers Squibb, Celltech-Medeva, Cypress Biosciences, Forest, GlaxoSmithKline, Johnson & Johnson, Lilly, New River, Novartis, Otsuka, Pfizer, Sanofi-Aventis, Shire, Solvay, Supernus Pharmaceuticals and Wyeth.

Notes