Evolving strategies in the management of aspergillosis

Abstract

Aspergillus spp. remain the most common causes of invasive mould infections among patients with hematologic malignancies and recipients of solid-organ and hematopoietic stem-cell transplants. Despite advances in prevention and treatment, invasive aspergillosis continues to be a deadly disease. This paper reviews current approaches to treatment of aspergillosis in adults, including surgical and immune-based strategies, and developments in prophylaxis for aspergillosis in high-risk patient populations.

Keywords::

• antifungal agents
• aspergillosis
• Aspergillus
• hematopoietic stem cell transplantation
• mycoses
• solid-organ transplantation