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Expert Opinion on Biological Therapy Volume 13, 2013 - Issue 6
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Epidermal stem cells: an update on their potential in regenerative medicine

Xiaoyan SunWound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P. R. China+0086 10 66936345; +0086 10 66936345; [email protected];Department of Dermatology, UC Davis School of Medicine, Suite 1630, 2921 Stockton Blvd, Sacramento, CA 95817, USA;Department of Ophthalmology, Sacramento, CA, USA;Institute for Regenerative Cures, UC Davis School of Medicine, Suite 1630, 2921 Stockton Blvd, Sacramento, CA 95817, USA
, MD PhD,
Xiaobing FuWound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P. R. China+0086 10 66936345; +0086 10 66936345; [email protected]
, MD PhD,
Weidong HanWound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Trauma Center of Postgraduate Medical School, Chinese PLA General Hospital, 28 Fu Xing Road, Beijing 100853, P. R. China+0086 10 66936345; +0086 10 66936345; [email protected]
, MD PhD,
Min ZhaoDepartment of Dermatology, UC Davis School of Medicine, Suite 1630, 2921 Stockton Blvd, Sacramento, CA 95817, USA;Department of Ophthalmology, Sacramento, CA, USA;Institute for Regenerative Cures, UC Davis School of Medicine, Suite 1630, 2921 Stockton Blvd, Sacramento, CA 95817, USA
, MD PhD &
Laura ChalmersDepartment of Dermatology, UC Davis School of Medicine, Suite 1630, 2921 Stockton Blvd, Sacramento, CA 95817, USA;Department of Ophthalmology, Sacramento, CA, USA;Institute for Regenerative Cures, UC Davis School of Medicine, Suite 1630, 2921 Stockton Blvd, Sacramento, CA 95817, USA
, PhD
Pages 901-910 | Published online: 21 Mar 2013
 
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Abstract

Introduction: Adult epidermal stem cells are crucial for skin tissue regeneration during homeostasis and disease. Recent updates relating to the function, cellular role and properties of these cells have been published. Notably, a recent study showed that keratinocytes may possess a transcriptional profile that is more amenable to reprogramming and this may open new avenues for exploring novel strategies to create patient-specific cell therapies.

Areas covered: In this paper, an overview of recent research pertaining to epidermal stem cells' properties and location, and their capacity for differentiation and transdifferentiation, as well as potential for tumorigenesis are presented.

Expert opinion: More efforts should be made to develop effective approaches to induce lineage conversion between different cell types and tailor the treatment to specific patient, while minimizing cancer risk.

Notes

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