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Abstract
Introduction: Patients with severe eosinophilic asthma have an unmet need for novel and efficacious treatments. Reslizumab is one of the three monoclonal antibodies targeting the IL-5 pathway and has been found in Phase IIIb clinical trials to reduce asthma exacerbations, control asthma-related symptoms and improve pulmonary function in patients with eosinophilic asthma.
Areas covered: In this article, we discuss the results of asthma clinical trials using reslizumab, beginning with a discussion of the relationship between eosinophils, IL-5 and asthma. We conducted PubMed searches using the terms ‘reslizumab’, ‘anti-IL-5’, ‘eosinophilic asthma’, ‘IL-5 asthma’. We also searched ClinicalTrials.gov for ‘reslizumab’, ‘reslizumab asthma’, ‘SCH 55700’, ‘SCH 55700 asthma’, ‘Cinquil’ and ‘Cinquil asthma’.
Expert opinion: Reslizumab and other anti-IL-5 therapies have seen success in recent trials through more stringent study participant selection targeting eosinophilic inflammation. This selection can now be based on simple blood counts. These drugs have shown a very good safety profile, but long-term safety data are not yet available. Approval for these drugs is eagerly awaited by clinicians and patients alike.
Declaration of interest
E Israel has received consultancy fees from AstraZeneca, travel grant support from TEVA specialty pharmaceuticals and research grants from Genentech. JC Cardet was supported by a diversity research supplement from NIAID (Grant No: U19AI095219). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.