Interleukin-18 as a potential therapeutic target in chronic autoimmune/inflammatory conditions

Abstract

Interleukin-18 (IL-18), a recently identified immunoregulatory and inflammatory cytokine, has attracted a profound interest as a potential therapeutic target in autoimmune/inflammatory disorders. In this review the authors focus on: IL-18 biology as an important link between innate and adaptive immunity; evidence of its pro-inflammatory role in several human autoimmune and chronic inflammatory disorders; and data indicating that IL-18 blockade in animal models results in prevention/amelioration of the disease process and preservation of the target tissue integrity and function. Finally, the authors analyse strategies presently under development to block IL-18 function and potential pitfalls resulting from IL-18 blockade that should be considered in ongoing/future clinical trials.

Keywords::

• adult-onset Still’s disease
• Crohn’s disease
• collagen-induced arthritis
• experimental colitis
• IL-18
• IL-18BP
• non-obese diabetic mice
• rheumatoid arthritis
• psoriasis
• Sjogren’s syndrome

Acknowledgements

MB is a recipient of an Arthritis Research Campaign (ARC) Clinical Research Fellowship.