The potential of muscle-derived stem cells for stress urinary incontinence

Abstract

The suburethral sling procedures, such as transvaginal tape (TVT), have recently gained popularity for the treatment of stress urinary incontinence (SUI). This TVT procedure can reinforce the weakness of pelvic floor muscles but urethral sphincter deficiency remains. Adult stem cell injection therapy for SUI has recently been at the forefront of the repair of deficient urethral function. Muscle-derived stem cells and adipose-derived stem cells are regarded as candidates for the treatment of SUI because these stem cells can be easily obtained in large quantities under local anesthesia, they have the potential to undergo long-term proliferation, self-renewal and multipotent differentiation, and can serve as a vehicle of releasing neurotrophins, such as nerve growth factor, to repair the deficient urethra.

Keywords::

• adipose
• muscle
• nerve growth factor
• stem cells
• urinary incontinence

Acknowledgement

The authors' SUI research has been supported by NIH grants (DK67226, AR49398 and DK55387) and Cook MyoSite funding.