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Expert Opinion on Biological Therapy Volume 7, 2007 - Issue 7
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Drug Evaluation

The effect of interferon-β on black holes in patients with multiple sclerosis

Francesca Bagnato National Institute of Health, National Institute for Neurological Diseases and Stroke, Neuroimmunology Branch, Building 10, Room 5B16, 10 Center Drive MSC 1400, Bethesda, MD, 20892-1400, USA +1 301 594 1415;+1 301 402 0373;[email protected]
, MD PhD,
Iordanis E Evangelou National Institute of Health, National Institute for Neurological Diseases and Stroke, Neuroimmunology Branch, Building 10, Room 5B16, 10 Center Drive MSC 1400, Bethesda, MD, 20892-1400, USA +1 301 594 1415;+1 301 402 0373;[email protected]
, DPhil,
Antonio Gallo National Institute of Health, National Institute for Neurological Diseases and Stroke, Neuroimmunology Branch, Building 10, Room 5B16, 10 Center Drive MSC 1400, Bethesda, MD, 20892-1400, USA +1 301 594 1415;+1 301 402 0373;[email protected]
, MD,
Deeya Gaindh National Institute of Health, National Institute for Neurological Diseases and Stroke, Neuroimmunology Branch, Building 10, Room 5B16, 10 Center Drive MSC 1400, Bethesda, MD, 20892-1400, USA +1 301 594 1415;+1 301 402 0373;[email protected]
, AB &
Karen Yao National Institute of Health, National Institute for Neurological Diseases and Stroke, Neuroimmunology Branch, Building 10, Room 5B16, 10 Center Drive MSC 1400, Bethesda, MD, 20892-1400, USA +1 301 594 1415;+1 301 402 0373;[email protected]
, PhD
Pages 1079-1091 | Published online: 31 Jul 2007
 
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Abstract

Multiple sclerosis (MS) is an immunological disorder of the CNS. Linked to an initial transient inflammation as the result of blood–brain barrier leakage, the disease progresses into a neurodegenerative phase. MRI is the most powerful paraclinical tool for diagnosing and monitoring MS. Although contrast enhancing lesions are the visible events of blood–brain barrier breakdown, accumulation of hypointense lesions, namely black holes, are recognised as irreversible axonal loss. IFN-β is administered as a first-line drug in MS patients. However, whether the effect of IFN-β extends beyond just prevention of blood–brain barrier leakage and further prevents the formation of black holes or promotes their recovery once formed, is not yet understood.

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