Tumour-immune cell interactions modulated by chemokines

Abstract

Background: Chemokines are involved in almost all aspects of tumour establishment and progression. Objective: This review gives an insight into the complexity of chemokines and chemokine signalling in tumours, especially focusing on the tuning of the immune system within the tumour microenvironment. Methods: Experimental evidence from manipulation of the chemokine network in murine models and in vitro data are critically discussed, and the current status and potential future interventions therapeutically targeting chemokines for efficient and long-lasting tumour control in cancer patients are described.

Keywords::

• cancer
• chemokine
• chemokine receptor
• immune cells
• immunotherapy

Acknowledgements

The authors are grateful to Rajam Csordas for critical reading and editorial assistance. The authors apologise to colleagues whose work may have been only cited indirectly through reviews due to space constraints.

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