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Expert Opinion on Emerging Drugs Volume 20, 2015 - Issue 4
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Review

Emerging drugs for the treatment of bone metastasis

Francesco PantanoCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, MD PhD,
Michele IulianiCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, PhD,
Alice ZoccoliCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, PhD,
Marco FioramontiCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, PhD student,
Delia De LisiCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, MD,
Iacopo FioroniCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, MD,
Giulia RibelliCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, PhD student,
Matteo SantoniUniversità Politecnica delle Marche, AOU Ospedali Riuniti, Medical Oncology Department, Ancona, Italy
, MD,
Bruno VincenziCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, MD PhD,
Giuseppe ToniniCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, MD PhD &
Daniele SantiniCampus Bio-Medico University of Rome, Medical Oncology Department, Via Alvaro del Portillo 200, 00128 Rome, Italy+39 062 254 191 17; +39 062 254 119 33; [email protected]
, MD PhD show all
Pages 637-651 | Published online: 25 Jun 2015
 
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Abstract

Introduction: Bone metastases are virtually incurable resulting in significant disease morbidity, reduced quality of life and mortality. Bone provides a unique microenvironment whose local interactions with tumor cells offer novel targets for therapeutic interventions. Increased understanding of the pathogenesis of bone disease has led to the discovery and clinical utility of bone-targeted agents other than bisphosphonates and denosumab, currently, the standard of care in this setting.

Areas covered: In this review, we present the recent advances in molecular targeted therapies focusing on therapies that inhibit bone resorption and/or stimulate bone formation and novel anti-tumoral agents that exerts significant effects on skeletal metastases, nowadays available in clinical practice or in phase of development.

Expert opinion: New emergent bone target therapies radium-223, mTOR inhibitors, anti-androgens have demonstrated the ability to increase overall survival in bone metastatic patients, other compounds, such as ET-1 and SRC inhibitors, up to now failed to clearly confirm in clinical trials their promising preclinical data.

Declaration of interest

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

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