Advanced search
Publication Cover
Expert Opinion on Therapeutic Targets Volume 15, 2011 - Issue 7
Submit an article Journal homepage
990
Views
166
CrossRef citations to date
0
Altmetric
Reviews

Overcoming drug resistance in pancreatic cancer

Jiang LongBaylor College of Medicine, Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Houston, Texas 77030, USA;Fudan University, Pancreatic Cancer Center/Institute, Shanghai Medical College, Cancer Hospital, Department of Pancreas & Hepatobiliary Surgery, 270 Dong'an Road, Shanghai 200032, People's Republic of China
,
Yuqing ZhangBaylor College of Medicine, Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Houston, Texas 77030, USA
,
Xianjun YuFudan University, Pancreatic Cancer Center/Institute, Shanghai Medical College, Cancer Hospital, Department of Pancreas & Hepatobiliary Surgery, 270 Dong'an Road, Shanghai 200032, People's Republic of China
,
Jingxuan YangBaylor College of Medicine, Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Houston, Texas 77030, USA;The University of Texas Health Science Center at Houston, Medical School, The Vivian L. Smith Department of Neurosurgery, 6431 Fannin Street, MSB 3.000, Houston, TX 77030, USA+1 713 500 6491; [email protected]
,
Drake G LeBrunThe University of Texas Health Science Center at Houston, Medical School, The Vivian L. Smith Department of Neurosurgery, 6431 Fannin Street, MSB 3.000, Houston, TX 77030, USA+1 713 500 6491; [email protected]
,
Changyi ChenBaylor College of Medicine, Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Houston, Texas 77030, USA
,
Qizhi YaoBaylor College of Medicine, Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Houston, Texas 77030, USA
&
Min LiBaylor College of Medicine, Molecular Surgeon Research Center, Elkins Pancreas Center, Michael E. DeBakey Department of Surgery, Houston, Texas 77030, USA;The University of Texas Health Science Center at Houston, Medical School, The Vivian L. Smith Department of Neurosurgery, 6431 Fannin Street, MSB 3.000, Houston, TX 77030, USA+1 713 500 6491; [email protected]
 show all
Pages 817-828 | Published online: 11 Mar 2011
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Introduction: Pancreatic cancer has the worst survival rate of all cancers. The current standard care for metastatic pancreatic cancer is gemcitabine, however, the success of this treatment is poor and overall survival has not improved for decades. Drug resistance (both intrinsic and acquired) is thought to be a major reason for the limited benefit of most pancreatic cancer therapies.

Areas covered: Previous studies have indicated various mechanisms of drug resistance in pancreatic cancer, including changes in individual genes or signaling pathways, the influence of the tumor microenvironment, and the presence of highly resistant stem cells. This review summarizes recent advances in the mechanisms of drug resistance in pancreatic cancer and potential strategies to overcome this.

Expert opinion: Increasing drug delivery efficiency and decreasing drug resistance is the current aim in pancreatic cancer treatment, and will also benefit the treatment of other cancers. Understanding the molecular and cellular basis of drug resistance in pancreatic cancer will lead to the development of novel therapeutic strategies with the potential to sensitize pancreatic cancer to chemotherapy, and to increase the efficacy of current treatments in a wide variety of human cancers.

Acknowledgements

We thank R Hwang for valuable suggestions.

Notes

This box summarizes key points contained in the article.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 99.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,049.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.