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Expert Opinion on Drug Safety Volume 7, 2008 - Issue 2
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Review

The safety of diclofenac for the management and treatment of actinic keratoses

Fariba Iraji Isfahan University of Medical Sciences, AlZahra Hospital, Skin Diseases and Leishmaniasis Research Center, Dermatology Department, Isfahan, Iran +98 913 108 9153; +98 311 6684510; [email protected]
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Amir Hossein Siadat Isfahan University of Medical Sciences, AlZahra Hospital, Skin Diseases and Leishmaniasis Research Center, Dermatology Department, Isfahan, Iran +98 913 108 9153; +98 311 6684510; [email protected]
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Ali Asilian Isfahan University of Medical Sciences, AlZahra Hospital, Skin Diseases and Leishmaniasis Research Center, Dermatology Department, Isfahan, Iran +98 913 108 9153; +98 311 6684510; [email protected]
,
Shahla Enshaieh Isfahan University of Medical Sciences, AlZahra Hospital, Skin Diseases and Leishmaniasis Research Center, Dermatology Department, Isfahan, Iran +98 913 108 9153; +98 311 6684510; [email protected]
&
Zabiholah Shahmoradi Isfahan University of Medical Sciences, AlZahra Hospital, Skin Diseases and Leishmaniasis Research Center, Dermatology Department, Isfahan, Iran +98 913 108 9153; +98 311 6684510; [email protected]
Pages 167-172 | Published online: 06 Mar 2008
 
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Abstract

Background: Actinic keratoses (AKs), defined as carcinoma in situ of squamous carcinoma, is usually induced by excessive sun exposure. The efficacy of 3% diclofenac in 2.5% hyaluronic acid gel for treatment of AKs has been documented in a few studies. Objective: Is diclofenac safe and effective for the management and treatment of AKs? Method: All the papers that were cited in Medline and ISI Web of Science are included in this study. Results/conclusion: The use of diclofenac is associated with a few side effects, which include pruritus, rashes, dry skin, and scaling. These side effects are usually minimal and tolerable; therefore, this topical medication is suggested as the first line of treatment for AKs.

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