Dose accuracy of a reusable insulin pen using a cartridge system with an integrated plunger mechanism

Abstract

Pen injection devices are a common method of administering insulin for patients with diabetes. Pen devices must comply with guidelines prepared by the International Organization for Standardization, which include device dose accuracy and precision. OptiClik^® (sanofi-aventis) was developed to fulfil unmet needs of patients with diabetes, including: easier cartridge changing, clearer dose display and readability, and a larger dose of insulin to be delivered with a single injection. In this paper, the authors report on the dose accuracy of the OptiClik pen device, which uses a novel cartridge system with an integrated plunger for easier cartridge changing. The authors show that OptiClik accurately delivers a required dose of insulin, which is maintained over the lifetime of the pen. OptiClik offers a significant contribution to the treatment of diabetes.

Keywords::

• delivery device
• insulin
• insulin delivery
• insulin pen
• OptiClik^®
• Type 1 diabetes
• Type 2 diabetes

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