pH-sensitive nano-crystals of carbonate apatite for smart and cell-specific transgene delivery

Abstract

The treatment of a human disease at a genetic level by either providing a cell with a functional gene or a nucleic acid sequence to precisely silence a harmful gene, is a powerful approach that could revolutionise clinical medicine. Despite the existence of both genetically engineered viral vectors and synthetically designed lipid- or polymer-based nanocarriers, an ideal delivery system in terms of safety and efficacy is still lacking. This editorial reports on the development of biocompatible, inorganic nanoparticles of carbonate apatite, which has the unique features essentially required for smart delivery, as well as for the expression of a genetic material in a mammalian cell.

Keywords::

• carbonate apatite
• DNA release
• endosomal acidification
• gene delivery
• nano-crystal
• particle dissolution
• targeted delivery
• transgene expression