Biodegradable polymeric nanocarriers for pulmonary drug delivery

Abstract

Background: Pulmonary drug delivery is attractive for both local and systemic drug delivery as a non-invasive route that provides a large surface area, thin epithelial barrier, high blood flow and the avoidance of first-pass metabolism. Objective: Nanoparticles can be designed to have several advantages for controlled and targeted drug delivery, including controlled deposition, sustained release, reduced dosing frequency, as well as an appropriate size for avoiding alveolar macrophage clearance or promoting transepithelial transport. Methods: This review focuses on the development and application of biodegradable polymers to nanocarrier-based strategies for the delivery of drugs, peptides, proteins, genes, siRNA and vaccines by the pulmonary route. Results/conclusion: The selection of natural or synthetic materials is important in designing particles or nanoparticle clusters with the desired characteristics, such as biocompatibility, size, charge, drug release and polymer degradation rate.

Keywords::

• biodegradable polymers
• gene and siRNA delivery
• nanoparticles
• peptides
• proteins
• pulmonary drug delivery

Acknowledgements

The authors wish to thank the German Ministry for Education and Research (BMBF) for a nanotechnology science award 13N8889 and Boehringer Ingelheim Pharma GmbH for technical support.