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Expert Opinion on Drug Metabolism & Toxicology Volume 6, 2010 - Issue 1
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Drug Evaluations

Lamivudine for the treatment of HIV

Princy N Kumar Professor of Medicine and Microbiology, Chief, Division of Infectious Diseases, Senior Associate Dean of Students, Georgetown University, 110 Kober Cogan Building, 3800 Reservoir Rd NW, Washington DC, 20007, USA +1 202 687 6845; +1 202 687 6476; [email protected]
, MD (Professor of Medicine and Microbiology, Chief, Division of Infectious Diseases, Senior Associate Dean of Students) &
Parul Patel GlaxoSmithKline, Five Moore Drive, P.O. Box 13398, Research Triangle Park, NC 27709, USA
, PharmD (Lead Clinical Development Scientist)
Pages 105-114 | Published online: 13 Dec 2009
 
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Abstract

Lamivudine is a nucleoside reverse transcriptase inhibitor that is widely used for the treatment of HIV-1 infection in combination with other antiretrovirals. It is a highly effective agent that can be dosed once or twice daily due to its long intracellular half-life. It also has one of the best tolerability and long-term safety profiles among all antiretroviral agents and continues to be preferred as part of initial or subsequent combination therapy in HIV-infected patients.

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