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Abstract
Importance of the field: Carvedilol, a non-selective β-blocker, has recently drawn attention because of its therapeutic benefits over other prescribed analogues for the treatment of cardiovascular diseases (CVDs).
Areas covered in this review: The present review attempts to present the clinical efficacy of carvedilol in comparison to other available β-blockers. The literature search was carried out in three electronic databases (Unbound Medline, Pubmed and Sciencedirect) and internet search engines (Scirus and Google Scholar) without time constraints to ensure maximum literature coverage.
What the reader will gain: A relatively large number of comparative studies have revealed that carvedilol has advantage over traditional β-blockers with respect to hemodynamic and metabolic effects, due to its unique non-selective α-/β-adrenoceptor affinity. Such results indicate its safe and effective therapeutic application particularly in patients with complicated CVDs, even in pediatric and geriatric patients.
Take home message: The therapeutic profile of carvedilol indicates its suitability for treatment of complicated CVDs than other non-selective β-blockers. However, there is a limitation in terms of its dose due to its low bioavailability (∼ 25%). Therefore, there is still need for bioavailability enhancement and dose reduction to further improve the therapeutic efficacy of the drug.
Acknowledgement
The first author gratefully acknowledges the financial assistance provided by Indian Council of Medical Research, New Delhi, in the form of Senior Research Fellowship for his doctoral research project.