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Expert Opinion on Medical Diagnostics Volume 3, 2009 - Issue 5
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Genetic testing in couples undergoing assisted reproduction technique protocols

Liborio Stuppia G. d' Annunzio University, Department of Biomedical Sciences, Via dei Vestini 35 66013, Chieti-Pescara, Italy +39 08713554137; +39 08713554135; [email protected]; Ce.S.I., G. d'Annunzio University Foundation, Ageing Research Center, Via dei Vestini 31, 66013 Chieti, Italy; I.G.M.-C.N.R., Unit of Bologna, c/o IOR, Via di Barbiano 1/10, 40136 Bologna, Italy
, MD,
Valentina Gatta G. d' Annunzio University, Department of Biomedical Sciences, Via dei Vestini 35 66013, Chieti-Pescara, Italy +39 08713554137; +39 08713554135; [email protected]; Ce.S.I., G. d'Annunzio University Foundation, Ageing Research Center, Via dei Vestini 31, 66013 Chieti, Italy
,
Ivana Antonucci G. d' Annunzio University, Department of Biomedical Sciences, Via dei Vestini 35 66013, Chieti-Pescara, Italy +39 08713554137; +39 08713554135; [email protected]; Ce.S.I., G. d'Annunzio University Foundation, Ageing Research Center, Via dei Vestini 31, 66013 Chieti, Italy
,
Rossella Giuliani G. d' Annunzio University, Department of Biomedical Sciences, Via dei Vestini 35 66013, Chieti-Pescara, Italy +39 08713554137; +39 08713554135; [email protected]
,
Anna Paola Scioletti Ce.S.I., G. d'Annunzio University Foundation, Ageing Research Center, Via dei Vestini 31, 66013 Chieti, Italy; G. d'Annunzio University, Department of Clinical Sciences and Bioimaging, Via dei Vestini 31, 66013 Chieti, Italy
&
Giandomenico Palka G. d' Annunzio University, Department of Biomedical Sciences, Via dei Vestini 35 66013, Chieti-Pescara, Italy +39 08713554137; +39 08713554135; [email protected]; Pescara Hospital, Human Genetic Division, Via Renato Paolini 47, 65100, Pescara, Italy
Pages 571-583 | Published online: 29 Jul 2009
 

Abstract

Background: An increasing number of couples undergo assisted reproduction techniques (ART) to generate a child, with the risk of the transmission to the offspring of a genetic defect underlying the condition of infertility. Objective: To review the most common genetic causes of infertility and identify the appropriate genetic testing to be carried out to reduce the risk of genetic defect in the offspring. Method: Review of the literature in the field. Results/conclusion: Cytogenetic investigation and screening of the CFTR gene are the only genetics testing suggested in all the couples undergoing ART; other tests should be performed only in selected cases.

Acknowledgments

This study was supported by grants from the University of Chieti (to L Stuppia, V Gatta and G Palka) and from the Italian Ministry of University and Research (to G Palka).

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