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Expert Review of Neurotherapeutics Volume 6, 2006 - Issue 10
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Review

Chemotherapy and targeted molecular therapies for brain metastases

Jan Drappatz Center for Neuro-oncology Dana-Farber/Brigham and Women’s Cancer Center, and Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital 44 Binney Street SW 430D, Boston, MA 02115, USA. [email protected]
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Patrick Y Wen Center for Neuro-oncology Dana-Farber/Brigham and Women’s Cancer Center, and Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital 44 Binney Street SW 430D, Boston, MA 02115, USA. [email protected]
Pages 1465-1479 | Published online: 10 Jan 2014
 
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Abstract

As therapy for systemic cancers improves, an increasing number of patients are developing brain metastases. Although conventional therapy with surgery, radiation therapy and radiosurgery has improved the outcome of a significant number of patients, many develop multiple lesions that are not amenable to standard treatments. In this review, the current role of chemotherapy and targeted molecular agents for brain metastases is summarized and future directions are discussed.

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