Amyloid A amyloidosis and systemic lupus erythematosus

Abstract

Amyloid A (AA) amyloidosis occurs secondary to long-standing inflammation and causes nephropathy and various internal manifestations, which leads to mortality. It is very rare in some rheumatic diseases, such as systemic lupus erythematosus (SLE). Therefore, there are few articles that report AA amyloidosis in SLE. This article focuses on the previously reported cases of 24 patients with SLE that are complicated by AA amyloidosis, and on the underlying mechanisms.

Keywords::

• amyloid A amyloidosis
• serum amyloid A protein
• systemic lupus erythematosus

Financial disclosure

The author has no relevant financial interests related to this manuscript, including employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.