Gene expression profiles of systemic lupus erythematosus and rheumatoid arthritis

Abstract

Gene expression profiling using microarray technology is being employed to define specific molecular mediators and pathways involved in immunobiology, to understand the intricate interplay of genes participating in the pathogenesis, and to develop biomarkers of disease activity in both systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). This review summarizes the latest information on the pathogenesis of SLE and RA and describes the utilization of microarray technology in these systemic autoimmune diseases.

Keywords::

• gene expression profile
• microarray
• rheumatoid arthritis
• systemic lupus erythematosus

Financial disclosure

This work is sponsored by the 408/2006 ETT grant (E Kiss) and Janos Bolyai Academic Research Fellowship (P Szodoray).