Oral ziprasidone in the treatment of patients with bipolar disorders: a critical review

Abstract

Ziprasidone, a benzisothiazolyl piperazine derivative of tiospirone, is a second-generation antipsychotic with high-affinity antagonism for 5-hydroxytryptophan (5HT)_2A, 5HT_2C, 5HT_1D and D₂ receptors, pre- and post-synaptic agonism for 5HT_1A receptors, and inhibition of reuptake for serotonin and norepinephrine. Initially approved for the treatment of adults with schizophrenia, ziprasidone has more recently received supplementary indications for acute manic and mixed episodes and as maintenance therapy for people affected by bipolar disorder. Based on MEDLINE citations up to November 2010 and hand-searched references, this article relating to ziprasidone addresses its short- and long-term efficacy and safety, according to the results of randomized clinical trials, open-label studies and real-world experiences. Emerging evidence indicates that in patients with bipolar disorder, ziprasidone provides valid efficacy and remarkable safety when administered alone for the treatment of manic and mixed episodes. The same applies when ziprasidone is administered in combination with lithium or valproate for the prevention of affective relapses and recurrences. Any conclusion on the potential of ziprasidone as an antidepressant should be postponed because of insufficient evidence.

Keywords::

• bipolar depression
• bipolar disorder
• mania
• manic-depressive disorder
• mixed episode
• ziprasidone

Financial & competing interests disclosure

Emilio Sacchetti has received funding for consultancy, research, advisory board membership and sponsored lectures from Abbott, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Danippon Sumitomo Pharma, Eli Lilly, GlaxoSmithKline, Innova Pharma, Italfarmaco, Janssen-Cilag, Lundbeck, Pfizer, Sanofi-aventis and Wyeth Lederie. Paolo Valsecchi has received funding for research and sponsored lectures from Abbott, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly, Innova Pharma, Janssen-Cilag, Lundbeck, Pfizer and Wyeth Lederie. Alessandro Galluzzo has received funding for research and sponsored lectures from Abbott, AstraZeneca, Boehringer Ingelheim, Bristol-Myers Squibb, Eli Lilly, Innova Pharma, Janssen-Cilag, Lundbeck, Pfizer and Wyeth Lederie. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.