Fertility medications and the risk of cancer

Abstract

Cancer is among the leading causes of death, and malignant diseases of the female genital tract are among the most common sites. Reproductive factors that are also associated with infertility have been identified as risk factors. Hormones are thought to play a role in the induction and promotion of some type of cancers. Hormonal preparations affect the endocrine milieu and, by acting on the reproductive organs themselves, could even have a direct effect on carcinogenesis. Numerous case–control and cohort studies have tried to determine whether fertility medication use increases cancer risk. Overall, the current data is reassuring but most research groups drew conclusions based on a small number of cases and after a relatively short follow-up. Proper counseling prior to fertility medication use is important and further studies on even larger patient groups with more cancer cases are needed to support widespread use of fertility medications.

Keywords::

• breast cancer
• cancer
• clomiphene citrate
• fertility medication
• gonadotropin
• ovarian cancer
• uterine cancer

Financial & competing interests disclosure

The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.